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Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants

Authors Hashimoto, K; Higuchi, M; Makino, B; Sakakibara, I; Kubo, M; Komatsu, Y; Maruno, M; Okada, M

Journal JOURNAL OF ETHNOPHARMACOLOGY , FEB 1999,2:64

DOI 10.1016/S0378-8741(98)00123-8 PubMed 10197755

Abstract The amounts of aristolochic acid I and II in four groups of medicinal plants from the Aristolochiaceae and some related plants were determined by high-pressure liquid chromatography, for Aristolochia was reported to produce interstitial nephritis caused by aristolochic acids during chronic use for the treatment of rheumatism, diuretic and analgesic. They were detected in all the plants that originated from the genus Aristolochia (Aristolochiaceae) and in some of the plants from the genus Asarum (Aristolochiaceae). The present results suggest that these medicinal plants should be prohibited to use for remedy due to the harmful effects attributed to aristolochic acids. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Species covered 细辛属 Asarum 马兜铃属 Aristolochia