中文
Ethnobotany of China

KINGDOM:Plantae || PHYLUM:Tracheophyta || CLASS:Magnoliopsida || ORDER:Lamiales || FAMILY:列当科 Orobanchaceae || GENUS: 地黄属 Rehmannia

地黄 Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & Mey.

Accepted name Rehmannia glutinosa (Gaertn.) Libosch. ex DC. (Orobanchaceae) WCVP · name match (author differs or missing)
Catalogue of Life China 地黄
Flora treatments

《中国植物志》|| 玄参科 SCROPHULARIACEAE ||地黄属 Rehmannia Libosch. ex Fisch. et Mey. ||地黄 Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & C. A. Mey.

1.地黄 生地、怀庆地黄(栽培)图59
Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey. Ind. Sem. Hort. Petrop. 1: 36. 1835; Benth. in DC. Prodr. 9: 275. 1845; 斐鉴、周太炎, 中国药用植物志139. 1953; 崔友文, 华北经济植物志(不包括浙江的); 乐天宇等, 陕甘宁盆地植物志207. 1957;中药志1: 197. 1957;中国高等植物图鉴4: 51.图5515. 1975. ——Digitalis glutinosa Gaertn. Nov. Comm. Acad. Petrop. 14: 544. t. 20, 1770.——Rehmannia chinensis Libosch. ex Fisch. et Mey. Ind. Sem. Hort. Petrop. 1: 36. 1835. ——Rehmannia glutinosa Libosh. var. hemsleyana Diels, Bot. Jahrb. 29: 569. 1900.——R. glutinosa Libosch. var. typica f. purpurea Matsuda Bot. Mag. Tokyo 32: 141. 1918. ——R. glutinosa Libosch. var. huechingensis Chao et Schih, 药物学报1: 41. 1957. ——Rehmannia glutinosa Libosch. f. huechingensis(Chao et Schih)Hsiao, 中药志1: 197. 1959.
体高10-30厘米,密被灰白色多细胞长柔毛和腺毛。根茎肉质,鲜时黄色,在栽培条件下,直径可达5.5厘米,茎紫红色。叶通常在茎基部集成莲座状,向上则强烈缩小成苞片,或逐渐缩小而在茎上互生;叶片卵形至长椭圆形,上面绿色,下面略带紫色或成紫红色,长2-13厘米,宽1-6厘米,边缘具不规则圆齿或钝锯齿以至牙齿;基部渐狭成柄,叶脉在上面凹陷,下面隆起。花具长0.5-3厘米之梗,梗细弱,弯曲而后上升,在茎顶部略排列成总状花序,或几全部单生叶腋而分散在茎上;萼长1-1.5厘米,密被多细胞长柔毛和白色长毛,具10条隆起的脉;萼齿5枚,矩圆状披针形或卵状披针形抑或多少三角形,长0.5-0.6厘米,宽0.2-0.3厘米,稀前方2枚各又开裂而使萼齿总数达7枚之多;花冠长3-4.5厘米;花冠筒多少弓曲,外面紫红色,被多细胞长柔毛;花冠裂片,5枚,先端钝或微凹,内面黄紫色,外面紫红色,两面均被多细胞长柔毛,长5-7毫米,宽4-10毫米;雄蕊4枚;药室矩圆形,长2.5毫米,宽1.5毫米,基部叉开,而使两药室常排成一直线,子房幼时2室,老时因隔膜撕裂而成一室,无毛;花柱顶部扩大成2枚片状柱头。蒴果卵形至长卵形,长1-1.5厘米。花果期4-7月。
分布于辽宁、河北、河南、山东、山西、陕西、甘肃、内蒙古、江苏、湖北等省区。生于海拔50-1100米之砂质壤土、荒山坡、山脚、墙边、路旁等处。此外,国内各地及国外均有栽培。根茎药用。


Source 中国植物物种信息数据库

Economic plants
Medicinal plants
根入药。“生地”有降低血糖的作用,并能解热、通经、利尿。熟地为滋养强壮药,治体虚、神经衰弱、贫血等症,具补血、强心之效。
[中国经济植物志338. 地黄 ( dihuang )]


Plant use records
Chinese name Vernacular name Plant Ethnic group Use Source
地黄 浩如古博钦-其其格 地黄 Rehmannia glutinosa (Gaetn. ) Libosch. ex Fish. et Mey. Mongolian medicine Ethnomedicinal
地黄 浩如古博钦-其其格 地黄 Rehmannia glutinosa (Gaetn. ) Libosch. ex Fish. et Mey. Mongolian medicine Ethnomedicinal
地黄 浩如古博钦-其其格 地黄 Rehmannia glutinosa (Gaetn. ) Libosch. ex Fish. et Mey. Mongolian medicine Ethnomedicinal 《蒙药》
地黄 大生地 地黄 Rehmannia glutinosa (Gaetn. ) Libosch. ex Fish. et Mey. Dai medicine Ethnomedicinal
地黄 大生地 地黄 Rehmannia glutinosa (Gaetn. ) Libosch. ex Fish. et Mey. Dai medicine Ethnomedicinal 《滇省志》
地黄 地黄 Rehmannia glutinosa (Gaetn. ) Libosch. ex Fish. et Mey. Miao medicine Ethnomedicinal 《湘蓝考》
地黄 地黄 地黄 Rehmannia glutinosa Libosch. Medicinal 中国药典2020
鲜地黄 鲜地黄 鲜地黄 Rehmannia glutinosa (Gaertn. ) Libosch. ex Fisch. et Mey. Medicinal 中华本草
干地黄 干地黄 干地黄 Rehmannia glutinosa (Gaertn. ) Libosch. ex Fisch. et Mey. Medicinal 中华本草
熟地黄 熟地黄 熟地黄 Rehmannia glutinosa (Gaertn. ) Libosch. ex Fisch. et Mey. Medicinal 中华本草


Historical formulas containing this species
Use in historical formulas by period (4 formulas in total)
Use in historical formulas by periodPre-Qin: 0Pre-QinHan: 0HanWei–Jin & N–S: 0Wei–Jin& N–SSui–Tang & Five Dynasties: 0Sui–Tang& Five DynastiesSong: 0SongJin–Yuan: 0Jin–YuanMing: 33MingQing: 11Qing




Wild economic plants of the Qinghai–Tibet Plateau (field survey)
Plant name Local name Family Life form Part used Folk use Voucher Locality Ethnic group Region

Research papers
Title Authors Journal Date
Progress in Medicinal Plant Rehmannia glutinosa: Metabolite Profiling, Tissue Culture, Growth and Its Regulation, and Functional Genomics Ling, H.; Liu, R. R. RUSSIAN JOURNAL OF PLANT PHYSIOLOGY SEP-OCT 2009
Catapol production in Chinese foxglove (Rehmannia glutinosa Libos.) hairy roots transformed with Agrobacterium rhizogenes ATCC15834. Hwang, Sung Jin Methods in molecular biology (Clifton, N.J.)
Effect of fermented medicinal plants on growth performance, nutrient digestibility, fecal noxious gas emissions, and diarrhea score in weanling pigs Zhao, Pinyao; Li, Hanlin; Lei, Yan; Li, Tianshui; Kim, Sunki; Kim, Inho JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE MAR 15 2016
Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions Prieto, JM; Recio, MC; Giner, RM; Manez, S; Giner-Larza, EM; Rios, JL JOURNAL OF PHARMACY AND PHARMACOLOGY SEP 2003
Application of plant biotechnology in the medicinal plant, Rehmannia glutinosa Liboschitz Park, Sang Un; Park, Nam Il; Kim, Yong Kyoung; Suh, Seung Yeon; Eom, Seok Hyun; Lee, Sook Young JOURNAL OF MEDICINAL PLANTS RESEARCH DEC 2009
Rehmannia glutinosa: Review of botany, chemistry and pharmacology Zhang, Ru-Xue; Li, Mao-Xing; Jia, Zheng-Ping JOURNAL OF ETHNOPHARMACOLOGY MAY 8 2008
Integrating traditional Chinese medicine healthcare into diabetes care by reducing the risk of developing kidney failure among type 2 diabetic patients: A population-based case control study Hsu, Pei-Chien; Tsai, Yueh-Ting; Lai, Jung-Nien; Wu, Chien-Tung; Lin, Shun-Ku; Huang, Chung-Yu JOURNAL OF ETHNOPHARMACOLOGY OCT 28 2014
Integrative therapy decreases the risk of lupus nephritis in patients with systemic lupus erythematosus: A population-based retrospective cohort study Chang, Ching-Mao; Wu, Po-Chang; Chiang, Jen-Huai; Wei, Yau-Huei; Chen, Fang-Pey; Chen, Tzeng-Ji; Pan, Tai-Long; Yen, Hung-Rong; Chang, Hen-Hong JOURNAL OF ETHNOPHARMACOLOGY JAN 20 2017
Bioassay-guided isolation of norviburtinal from the root of Rehmannia glutinosa, exhibited angiogenesis effect in zebrafish embryo model Liu, Cheuk-Lun; Cheng, Ling; Kwok, Hin-Fai; Ko, Chun-Hay; Lau, Tai-Wai; Koon, Chi-Man; Zhao, Ming; Lau, Ching-Po; Lau, Kit-Man; Wong, Chun-Wai; Leung, Ping-Chung; Fung, Kwok-Pui; Lau, Clara Bik-San JOURNAL OF ETHNOPHARMACOLOGY OCT 11 2011
Historical and pharmacological studies on rehmannia root processing-Trends in usage and comparison of the immunostimulatory effects of its products with or without steam processing and pretreatment with liquor Ota, Misato; Nakazaki, Junko; Tabuchi, Yoshiaki; Ono, Takahiko; Makino, Toshiaki JOURNAL OF ETHNOPHARMACOLOGY OCT 5 2019
Effect of Chinese herbs on CYP3A4 activity and expression in vitro Lau, C.; Mooiman, K. D.; Maas-Bakker, R. F.; Beijnen, J. H.; Schellens, J. H. M.; Meijerman, I. JOURNAL OF ETHNOPHARMACOLOGY SEP 2013
The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance Dai, Bing; Wu, Qinxuan; Zeng, Chengxi; Zhang, Jiani; Cao, Luting; Xiao, Zizeng; Yang, Menglin JOURNAL OF ETHNOPHARMACOLOGY NOV 4 2016
Anti-inflammatory activity of the Tongmai Yangxin pill in the treatment of coronary heart disease is associated with estrogen receptor and NF-kappa B signaling pathway Fan, Yadong; Liu, Jianwei; Miao, Jing; Zhang, Xiaoyu; Yan, Yiqi; Bai, Liding; Chang, Jun; Wang, Ying; Wang, Li; Bian, Yuhong; Zhou, Huifang JOURNAL OF ETHNOPHARMACOLOGY AUG 10 2021
A metabolic profiling analysis of the acute hepatotoxicity and nephrotoxicity of Zhusha Anshen Wan compared with cinnabar in rats using H-1 NMR spectroscopy Wang, Haifeng; Bai, Jiao; Chen, Gang; Li, Wen; Xiang, Rongwu; Su, Guangyue; Pei, Yuehu JOURNAL OF ETHNOPHARMACOLOGY MAR 27 2013
San Wu Huangqin decoction regulates inflammation and immune dysfunction induced by influenza virus by regulating the NF-kappa B signaling pathway in H1N1-infected mice Ma, Qin-hai; Ren, Meng-yue; Luo, Jia-bo JOURNAL OF ETHNOPHARMACOLOGY JAN 10 2021
Screening of the optimized prescription from Suqingwan in terms of its therapeutic effect on DSS-induced ulcerative colitis by its regulation of inflammatory and oxidative mediators Shao, Jingxuan; Liu, Zhihui; Wang, Lin; Song, Zehai; Chang, Hang; Han, Na; Yin, Jun JOURNAL OF ETHNOPHARMACOLOGY APR 18 2017
Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat Liu, Ji-ping; Feng, Liang; Zhang, Ming-hua; Ma, Dong-ying; Wang, Shu-yuan; Gu, Junfei; Fu, Qiang; Qu, Rong; Ma, Shi-ping JOURNAL OF ETHNOPHARMACOLOGY OCT 28 2013
The effects of Liuwei Dihuang on canonical Wnt/beta-catenin signaling pathway in osteoporosis Xia, Bingjiang; Xu, Bing; Sun, Yan; Xiao, Luwei; Pan, Jiafei; Jin, Hongting; Tong, Peijian JOURNAL OF ETHNOPHARMACOLOGY APR 11 2014
DPPH-HPLC-MS assisted rapid identification of endothelial protective substances from Xiao-Ke-An Yang, Zhenzhong; Li, Zhenhao; Li, Zheng JOURNAL OF ETHNOPHARMACOLOGY JAN 30 2018
Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-D-aspartate receptor (NMDA) receptors Huang, Yan; Zhang, Heping; Yang, Sheng; Qiao, Haifa; Zhou, Wenxia; Zhang, Yongxiang JOURNAL OF ETHNOPHARMACOLOGY MAR 27 2012
Food- and gender-dependent pharmacokinetics of paeoniflorin after oral administration with Samul-tang in rats Hwang, Youn-Hwan; Kim, Taesoo; Cho, Won-Kyung; Jang, Doorye; Ha, Jung-Ho; Ma, Jin Yeul JOURNAL OF ETHNOPHARMACOLOGY FEB 10 2020
Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate cyclophosphamide-induced ongoing bladder overactivity and acidic adenosine triphosphate solution-induced hyperactivity on rats prestimulated bladder Lee, Wei-Chia; Wu, Chia-Ching; Chuang, Yao-Chi; Tain, You-Lin; Chiang, Po-Hui JOURNAL OF ETHNOPHARMACOLOGY MAR 15 2016
Molecular mechanisms of angiogenesis effect of active sub-fraction from root of Rehmannia glutinosa by zebrafish sprout angiogenesis-guided fractionation Liu, Cheuk-Lun; Kwok, Hin-Fai; Cheng, Ling; Ko, Chun-Hay; Wong, Chun-Wai; Ho, Tina Wai Fong; Leung, Ping-Chung; Fung, Kwok-Pui; Lau, Clara Bik-San JOURNAL OF ETHNOPHARMACOLOGY OCT 28 2021
Triptolide-induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol Zhou, Lingling; Zhou, Cong; Feng, Zhe; Liu, Zhangpu; Zhu, Huaxu; Zhou, Xueping JOURNAL OF ETHNOPHARMACOLOGY MAR 25 2018
Exploration of the potential mechanism of the Tao Hong Si Wu Decoction for the treatment of postpartum blood stasis based on network pharmacology and in vivo experimental verification Xia, Wenwen; Hu, Shoushan; Wang, Mengmeng; Xu, Fan; Han, Lan; Peng, Daiyin JOURNAL OF ETHNOPHARMACOLOGY MAR 25 2021
Bioassay-guided isolation of anti-inflammatory components from the root of Rehmannia glutinosa and its underlying mechanism via inhibition of iNOS pathway Liu, Cheuk-Lun; Cheng, Ling; Ko, Chun-Hay; Wong, Chun-Wai; Cheng, Wai-Hing; Cheung, David Wing-Shing; Leung, Ping-Chung; Fung, Kwok-Pui; Lau, Clara Bik-San JOURNAL OF ETHNOPHARMACOLOGY OCT 11 2012
Jin Gui Shen Qi Wan, a traditional Chinese medicine, alleviated allergic airway hypersensitivity and inflammatory cell infiltration in a chronic asthma mouse model Kao, Shung-Te; Wang, Shulhn-Der; Lin, Chih-Che; Lin, Li-Jen JOURNAL OF ETHNOPHARMACOLOGY DEC 5 2018
Comparisons of antithrombosis, hematopoietic effects and chemical profiles of dried and rice wine-processed Rehmanniae Radix extracts Gong, Pu-Yang; Tian, Yu-Shan; Guo, Yu-Jie; Gu, Li-Fei; Li, Jun-Yi; Qi, Jin; Yu, Bo-Yang JOURNAL OF ETHNOPHARMACOLOGY
Rehmannia glutinosa (Gaertn.) DC. polysaccharide ameliorates hyperglycemia, hyperlipemia and vascular inflammation in streptozotocin-induced diabetic mice Zhou, Jun; Xu, Gang; Yan, Junyan; Li, Kaicheng; Bai, Zhaoshuai; Cheng, Weinan; Huang, Kaixun JOURNAL OF ETHNOPHARMACOLOGY AUG 2018
Active fraction combination from Liuwei Dihuang decoction (LW-AFC) ameliorates corticosterone-induced long-term potentiation (LTP) impairment in mice in vivo Huang, Yan; Li, Dong; Cheng, Bin; Liu, Gang; Zhang, Yong-Xiang; Zhou, Wen-Xia JOURNAL OF ETHNOPHARMACOLOGY JAN 10 2021
Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats Shi, Cheng-jin; Wen, Xue-Sen; Gao, Hui-feng; Liu, Zhi-hua; Xu, Xu-kang; Li, Li-fen; Shen, Tao; Xian, Cory J. JOURNAL OF ETHNOPHARMACOLOGY
Metabolomics coupled with SystemsDock reveal the protective effect and the potential active components of Naozhenning granule against traumatic brain injury Cao, Jianhua; Duan, Yahui; Liu, Yanzhi; Liu, Haixia; Wei, Chunhong; Wang, Jiang; Qin, Xuemei; Wang, Xuwen; Li, Zhenyu JOURNAL OF ETHNOPHARMACOLOGY JAN 10 2020
Hematopoietic effects and mechanisms of Fufang E''jiao Jiang on radiotherapy and chemotherapy-induced myelosuppressed mice Liu, Maoxuan; Tan, Haining; Zhang, Xinke; Liu, Zhang; Cheng, Yanna; Wang, Dongliang; Wang, Fengshan JOURNAL OF ETHNOPHARMACOLOGY MAR 28 2014
Yeast exposure in the preparation of steamed rehmannia root improving its effects on alloxan-induced diabetic rats Sun, Yujing; Wen, Xuesen; Zhao, Yu; Shen, Tao; Liu, Zhihua; Gao, Huifeng; Qiu, Shubing; Chen, Ying JOURNAL OF ETHNOPHARMACOLOGY MAY 9 2018
Anti-platelet and anti-thrombotic effect of a traditional herbal medicine Kyung-Ok-Ko Kim, Tae-Ho; Lee, Kyoung Mee; Hong, Nam Doo; Jung, Yi-Sook JOURNAL OF ETHNOPHARMACOLOGY FEB 3 2016
Administration of Kyung-Ok-Ko reduces stress-induced depressive behaviors in mice through inhibition of inflammation pathway Liu, Quan Feng; Park, Sun-Woo; Kim, Young-Mi; Song, Sue-jin; Chin, Young-Won; Pak, Sok Cheon; Jeon, Songhee; Koo, Byung-Soo JOURNAL OF ETHNOPHARMACOLOGY JAN 30 2021
Toxicity of medicinal plant extracts to Lycoriella ingenua (Diptera: Sciaridae) and Coboldia fuscipes (Diptera: Scatopsidae) Yi, Jee-Hwan; Park, Il-Kwon; Choi, Kwang-Sik; Shin, Sang-Cheol; Ahn, Youngjoon Journal of Asia-Pacific Entomology 2008
Indigenous paraquat resistance in Korean foxglove (Rehmannia glutinosa Libosch.) and in vivo multiple adventitious buds formation Park, C; Park, H; Seong, N; Simon, JE FUTURE FOR MEDICINAL AND AROMATIC PLANTS
Soil Microbial Community Composition and Diversity in the Rhizosphere of a Chinese Medicinal Plant Qi, Jianjun; Yao, Huaiying; Ma, Xiaojun; Zhou, Lili; Li, Xianen COMMUNICATIONS IN SOIL SCIENCE AND PLANT ANALYSIS 2009
In Vivo Screening of Traditional Medicinal Plants for Neuroprotective Activity against A beta 42 Cytotoxicity by Using Drosophila Models of Alzheimer''s Disease Liu, Quan Feng; Lee, Jang Ho; Kim, Young-Mi; Lee, Soojin; Hong, Yoon Ki; Hwang, Soojin; Oh, Youngje; Lee, Kyungho; Yun, Hye Sup; Lee, Im-Soon; Jeon, Songhee; Chin, Young-Won; Koo, Byung-Soo; Cho, Kyoung Sang BIOLOGICAL & PHARMACEUTICAL BULLETIN DEC 2015
Effect of probiotic bacteria-fermented medicinal plants (Gynura procumbens, Rehmannia glutinosa, Scutellaria baicalensis) as performance enhancers in growing pigs Jeong, Jin Suk; Kim, In Ho ANIMAL SCIENCE JOURNAL JUN 2015
Simultaneous Determination of Isoquinoline Alkaloids in Medicinal Asiatic Plants by Ultrasound-Assisted Extraction and High-Performance Liquid Chromatography - Mass Spectrometry with Principal Component Analysis Filipiak-Szok, Anna; Kurzawa, Marzanna; Szlyk, Edward ANALYTICAL LETTERS JAN 27 2011
Enterobacter amnigenus W5: A potential causal agent for Rehmannia glutinosa replant problem Bu, Y. Q.; Xue, Y. R.; Gan, L. S.; Liu, C. H.; Shan, Z. J. ALLELOPATHY JOURNAL JUL 2014
Pioneers of Allelopathy: XVII. Wenxiong Lin Fang, Changxun ALLELOPATHY JOURNAL MAY 2021
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