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Pharmacokinetic comparative study of gastrodin after oral administration of Gastrodia elata Bl. extract and its compatibility with the different indigents of Ligusticum chuanxiong Hort. to rats

Authors Hu, Peng-yi; Yue, Peng-fei; Zheng, Qin; Yang, Ming; Zhang, Guo-song; Wu, Bin; Liu, Dan

Journal JOURNAL OF ETHNOPHARMACOLOGY , SEP 15 2016,:191

DOI 10.1016/j.jep.2016.06.007 PubMed 27267828

Abstract Ethnopharmacological relevance: Da Chuan Xiong Decoction Compound preparation (DCXDCP) is a classic TCM formula of an aqueous extract made from Chuanxiong Rhizoma (Ligusticum chuanxiong Hort., umbelliferae) and Tianma Rhizoma (Gastrodia elata BI., Orchidaceae). Gastrodin (GAS), a bioactive component of tianma, its pharmacokinetic (PK) behavior significantly changed after oral administration of DCXDCP compared with the extract of tianma. However, little is known about how the ingredients of chuanxiong influenced on the PIC of GAS.Aim of the study: To study the possible PK behavior differences of GAS after individually oral administration of tianma extract and tianma extract mixed with different active ingredients of chuanxiong to rats, as well as explore whether there were some herb-herb interactions.Materials and methods: Different DCXDCP suspensions were prepared by mixing tianma extract with different active ingredients of chuanxiong. The rats were randomly assigned to six groups and were orally treated with different DCXDCP. At different predetermined time points after administration, the concentrations of GAS in the rat plasma were determined using HPLC, and the main PK parameters were investigated.Results: The results showed that tetramethylpyrazine had no significant effects on the PK parameters of GAS (p > 0.05), whereas ferulic acid (FA), total phenolic acids and total alkaloids significantly increased AUC(0-infinity) (p < 0.05). In general the observed changes in the PK parameters of GAS in DCXDCP could be closely related to the total phenolic acids and total alkaloids.Conclusion: It could be shown that total phenolic acids and total alkaloids present in Ligusticum chuanxiong in addition to other components not tested yet play an important role in affecting the PK of gastrodin in DCXDCP. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Species covered 天麻(原变型) Gastrodia elata 川芎 Ligusticum chuanxiong