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Neuroprotective potency of some spice herbs, a literature review

Authors Khazdair, Mohammad Reza; Anaeigoudari, Akbar; Hashemzehi, Milad; Mohebbati, Reza

Journal JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE , APR 2019,2:9

DOI 10.1016/j.jtcme.2018.01.002 PubMed 30963044

Abstract In recent years, growing attention has been given to traditional medicine. In traditional medicine a large number of plants have been used to cure neurodegenerative diseases such as Alzheimer''s disease (AD) and other memory related disorders. Crocus sativus (C. sativus), Nigella sativa (N. sativa), Coriandrum sativum (C. sativum), Ferula assafoetida (F. assafoetida), Thymus vulgaris (T. vulgaris), Zataria multiflora (Z. multiflora) and Curcuma longa (C. longa) were used traditionally for dietary, food additive, spice and various medicinal purposes. The Major components of these herbs are carotenoids, monoterpenes and poly phenol compounds which enhanced the neural functions.These medicinal plants increased anti-oxidant, decreased oxidant levels and inhibited acetylcholinesterase activity in the neural system. Furthermore, neuroprotective of plants occur via reduced proinflammatory cytokines such as IL-6, IL-1 beta, TNF-alpha and total nitrite generation.Therefore, the effects of the above mentioned medicinal and their active constituents improved neurodegenerative diseases which indicate their therapeutic potential in disorders associated with neuro-inflammation and neurotransmitter deficiency such as AD and depression. (C) 2018 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.

Species covered 姜黄 Curcuma longa 番红花 Crocus sativus 芫荽 Coriandrum sativum