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IMPROVEMENT BY GUAN-MU-TONG (CAULIS-ARISTOLOCHIAE-MANSHURIENSIS) OF LACTATION IN MICE

Authors WU, GJ; YAMAMOTO, K; MORI, T; INATOMI, H; NAGASAWA, H

Journal AMERICAN JOURNAL OF CHINESE MEDICINE , 1995,2:23

DOI 10.1142/S0192415X95000213 PubMed 7572777

Abstract Free access of 0.5% Guan-mu-tong (Gmt) as drinking water inhibited lactation of mice estimated by pup growth rate, which was associated with a decrease in RNA content and RNA/DNA ratio in the mammary glands, 0.05% Gmt improved pup growth rate and mammary DNA content. No pups were lost during the experiment. Similar results were obtained by 0.5% Xia-ru-yong-quan-tang (Xryqt), a Chinese herbal medicine, which contained 0.05% Gmt. Xryqt further prevented a decline in ovarian weight seen by 0.05 % Gmt treatment and significantly increased mother weight. These findings revealed two opposite effects of Gmt on mammary glands, stimulative and inhibitory, at low- and high-dose levels, respectively,

Species covered 马兜铃属 Aristolochia