Crystal and molecular structure of biatractylolide from the Chinese herb plant Atractylodes macrocephala

Authors Huang, ZQ; Lin, YC; Liu, SX; Chan, WL

Journal INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY , JAN 1999,1:38

Abstract Biatractylolide, a unique bisesquiterpenoid has been obtained from the Chinese herb plant Atractylodes macrocephala Koidz, [alpha](D)(20) +256(0) (c. 0.02,CHCl3). The single crystal belongs to space group PZ(1)Z(1)Z(1) with a = 10.972 Angstrom, b = 23.377 Angstrom, c = 9.840 Angstrom. The unit of cell contains four molecules. The structure has been solved by direct methodsand refined by least-squares method. Final R factor has been found to be 0.045. Prilimary assay of bioactivity shows that biatractylolide, as atractylolide, has the activity of releasing guinea pig ileum.

Species covered 白术 Atractylodes macrocephala