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Pharmacokinetics comparative study of a novel Chinese traditional herbal formula and its compatibility

Authors Zheng, Qin; Yue, Peng-Fei; Wu, Bin; Hu, Peng-Yi; Wu, Zhen-Feng; Yang, Ming

Journal JOURNAL OF ETHNOPHARMACOLOGY , SEP 1 2011,1:137

DOI 10.1016/j.jep.2011.05.007 PubMed 21605650

Abstract Ethnopharmacological relevance: Da Chuan Xiong Decoction Compound preparation (DCXDCP), the formulation of a classical Chinese prescription recorded in Xuanminglunfang, was clinically employed to treat migraine''s disease.Aim of the study: In order to investigate the influence of compatibility on the pharmacokinetics of the active ingredient Gastrodin (GAS), the comparative evaluations on pharmacokinetics of DCXDCP with various combinations of its constituent herbs in plasma after oral administration were studied.Materials and methods: The rats were randomly assigned to four groups and orally administered with different prescription proportion of Gastrodia elata BI. and Ligusticum chuanxiong Hort. (1:0; 1:0.25; 1:2.1; 1:4.2), respectively. At different predetermined time points after administration, the concentrations of GAS in rat plasma were determined by using HPLC, and main pharmacokinetic parameters were investigated.Results: The results showed that the pharmacokinetic parameters, AUC and C-max of GAS were dramatically different (p < 0.05) after oral administration of G. elate BI. and the different combinations of its constituent herbs.Conclusions: These indicated that the compatibility effects of other ingredients present in DCXDCP could affect the pharmacokinetics of the prescription. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Species covered 天麻(原变型) Gastrodia elata 川芎 Ligusticum chuanxiong