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Two new megastigmanes from Chinese traditional medicinal plant Sedum sarmentosum

Authors Ma, Xinhua; Yang, Jie; Deng, Shihao; Huang, Mi; Zheng, Sijian; Xu, Shicheng; Cai, Jinyan; Yang, Xinzhou; Ai, Honglian

Journal NATURAL PRODUCT RESEARCH , 2017,13:31

DOI 10.1080/14786419.2017.1280493 PubMed 28152607

Abstract To discover new bioactive compounds from nature plant, a primary screening of traditional Chinese medicine had been taken. The screening results showed that a EtOAc extract of Sedum sarmentosum displayed a certain degree of cytotoxic activity and bioassay-directed isolation of EtOAc extract gave two new megastigmanes, (6S, 9R)-2-hydroxy-4-(2,6,6-trimethyl-4-oxo-cyclohex-2-enyl)-butyric acid (1) and (6S, 9R)-2-hydroxy-4-(2,6,6-trimethyl-4-oxo-cyclohex-2-enyl)butyric acid methyl ester (2) together with seven known flavonoids. The chemical structures of 1 and 2 were elucidated on the basis of detailed 1D, 2D NMR and MS data. When tested against HepG2 and Hep3B hepatocellular carcinoma cell lines, compounds 1-9 showed weak anti-HCC activity. In addition, in vitro antioxidant activities of 1-9 were evaluated by ABTS radical cation-scavenging assay. 1 and 2 exhibited weak activity with per micromoles equivalent to 0.039 and 0.042 mu M of Trolox, respectively. The flavonoid component, quercetin (9) showed the highest antioxidant activities with per micromoles equivalent 0.67 mu M of Trolox.

Species covered 垂盆草 Sedum sarmentosum