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POTENT ANTITUMOR-ACTIVITY AND LOW TOXICITY OF TUBEIMOSIDE-1 ISOLATED FROM BOLBOSTEMMA-PANICULATUM

Authors YU, LJ; MA, RD; WANG, YQ; NISHINO, H

Journal PLANTA MEDICA , JUN 1994,3:60

DOI 10.1055/s-2006-959459 PubMed 8073083

Abstract Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a traditional Chinese medicinal plant (1), from which tubeimoside 1 was isolated. The antitumor activity and toxicity of tubeimoside 1 was investigated in vivo and in vitro. The results showed that tubeimoside 1 exerts potent anti-tumor activity with low toxicity. The compound inhibited DNA synthesis and induced phenotypic reverse transformation of tumor cells.

Species covered 假贝母 Bolbostemma paniculatum