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Comparison of the anti-inflammatory and anti-nociceptive effects of three medicinal plants known as Snow Lotus herb in traditional Uighur and Tibetan medicines

作者 Yi, Tao; Zhao, Zhong-Zhen; Yu, Zhi-Ling; Chen, Hu-Biao

期刊 JOURNAL OF ETHNOPHARMACOLOGY , MAR 24 2010,2:128

DOI 10.1016/j.jep.2010.01.037 PubMed 20083181

摘要 Ethnopharmacological relevance: Saussurea involucrata (Kar et Kir.) Sch.-Bip (Compositae) has long been used under the herbal name Snow Lotus for the treatment of rheumatoid arthritis, stomachache and dysmenorrhea in Uighur folk medicine In traditional Tibetan medicine, Saussurea laniceps Hand.-Mazz. and Saussurea medusa Maxim have also been used under the name Snow Lotus and prescribed for the treatment of pain and inflammatory conditionsAim of the study: The present study evaluated the pharmacological effects of three species of Snow Lotus in experimental inflammation and pain models, and determined the chemical compounds that may correlate with their pharmacological activitiesMaterials and methods The anti-inflammatory activities of the three herbs were observed by using carrageenan-induced paw edema in rats and xylene-induced ear edema in mice Investigations on the analgesic effects were conducted, including acetic acid-induced writhing and hot-plate test An UPLC-MS method was developed to analyze the chemical composition of the three herbs and of plasma samples after herb administration.Results: In rat paw edema model, the peak inhibitory effects of Saussurea laniceps and Saussurea involucrata (55.1% and 42 2%. respectively) were recorded with the dose of 400 mg/kg at 311 post-carrageenan injection. In mouse ear edema model, oral administration of Saussurea lamceps, Saussurea involucrata and Saussurea medusa extract (400 mg/kg) resulted in a significant inhibition of ear edema by 40 9%, 33 3%, and 9 1%, respectively In the writhing test, oral administration of Saussurea laniceps extract (100, 200 and 400 mg/kg) resulted in a significant inhibition of writhings by 13 5%, 22 3%, and 43.5%, respectively. In the hot-plate test. Saussurea laniceps extract significantly increased the latency of jumping response by 38.2% and 52 7% when treated orally at 200 and 400 mg/kg in mice, respectively Flavonoids, coumarins and lignins were found to be present in plasma after administration of the extracts and may be the basis of the observed pharmacological effectsConclusion The results clearly demonstrated that Saussurea laniceps was most effective, Saussurea involucrata exhibited a moderate potency, whereas Saussurea medusa possessed little effect against the experimental edema and pains This study also supported discrimination among the three herbs when using them in folk medicine. (C) 2010 Elsevier Ireland Ltd All rights reserved.

涉及物种 雪莲花 Saussurea involucrata 水母雪兔子 Saussurea medusa 绵头雪兔子 Saussurea laniceps