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Anti-inflammatory effects of 4 medicinal plant extracts in lipopolysaccharide-induced RAW 264.7 cells

Authors Jang, Mi; Jeong, Seung-Weon; Cho, Somi K.; Ahn, Kwang-Seok; Kim, Bum-Keun; Kim, Jong-Chan

Journal FOOD SCIENCE AND BIOTECHNOLOGY , FEB 2013,1:22

DOI 10.1007/s10068-013-0069-x

Abstract The anti-inflammatory activity of 4 plant extracts [guava (Psidium guajava) leaf, capillary wormwood (Artemisia capillaris Thunb.), Chinese goldthread (Coptis chinensis), and dandelion (Taraxacum platycarpum)] was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Six phenolic compounds (gallic acid, caffeic acid, chlorogenic acid, catechin, quercetin, and baicalin) were analyzed using LC-MS/MS. Guava leaf extracts showed the highest inhibitory effects on LPS-induced nitric oxide (NO, 52.58%) and prostaglandin E-2 (PGE(2), 43.45%) production. The total phenolic contents (TPC) in guava leaf, capillary wormwood, Chinese goldthread, and dandelion were 426.84, 154.42, 41.73, and 122.04 mg of gallic acid equivalent (GAE)/g of extract, respectively. TPC was positively correlated with the NO-inhibitory effect (r= 0.963, p < 0.05) and the PGE(2)-inhibitory effect (r=0.971, p < 0.05) at 30 mu g/mL of treatment. The guava leaf extracts contained the highest levels of gallic acid and catechin, while the capillary wormwood extracts contained the highest levels of chlorogenic acid and quercetin.

Species covered 茵陈蒿 Artemisia capillaris 黄连 Coptis chinensis 番石榴 Psidium guajava