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Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae - A review

Authors Lu, Jin-Jian; Dang, Yuan-Ye; Huang, Min; Xu, Wen-Shan; Chen, Xiu-Ping; Wang, Yi-Tao

Journal JOURNAL OF ETHNOPHARMACOLOGY , SEP 28 2012,2:143

DOI 10.1016/j.jep.2012.07.009 PubMed 22820242

Abstract Ethnopharmacological relevance: Rhizoma Curcumae is a popular type of traditional Chinese medicine whose essential oils are widely used in the treatment of cancer in China. This review aims to systematically summarize and analyze the anti-cancer properties of terpenoids, the main components of essential oils in Rhizoma Curcumae, and thus enable the development of new anti-cancer drugs.Materials and methods: Information on the recent progress of anti-cancer studies on terpenoids isolated from Rhizoma Curcumae, including beta-elemene, delta-elemene, furanodiene, furanodienone, curcumol, and germacrone, was gathered and analyzed.Results: Among these terpenoids, beta-elemene is the most widely studied, whereas delta-elemene, furanodiene, furanodienone, curcumol, and germacrone have just recently attracted the attention of researchers. The anti-cancer effects of these terpenoids are related to the retardation of cell cycle arrest, the induction of apoptosis, and the inhibition of metastasis or tissue invasion, among others.Conclusions: Most studies have focused on the in vitro data, and in vivo data is urgently needed. Further insight into the anti-cancer activity and the molecular basis of these compounds, combined with efforts in pharmaceutical chemistry and/or pharmaceutics, will potentially enable the development of new anti-cancer agents. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

Species covered 姜黄属 Curcuma