---

Neuroprotective effects of paeoniflorin in neurodegenerative diseases of the central nervous system

Authors Manayi, Azadeh; Omidpanah, Sahar; Barreca, Davide; Ficarra, Silvana; Daglia, Maria; Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad

Journal PHYTOCHEMISTRY REVIEWS , DEC 2017,6:16

DOI 10.1007/s11101-017-9527-z

Abstract Paeoniflorin is a monoterpene glycoside, the beta-glucoside of paeoniflorigenin. It is one of the major components of Radix Paeoniae, the herbal product obtained from Paeonia lactiflora Pall., a medicinal plant used in folk medicine, especially in Chinese Traditional Medicine, to treat several human ailments, including dementia and cognitive decline. The neuroprotective effects of paeoniflorin have been studied by many investigations showing that its beneficial effects may derive from its anti-inflammatory and anti-apoptotic properties, and its ability to promote neuronal survival. This review evaluates scientific evidence on the neuroprotective properties of paeoniflorin. On the basis of literature data, paeoniflorin seems to be a promising compound for the prevention and treatment of neurodegenerative disorders, though definitive recommendation requires further studies.

Species covered 芍药(原变种) Paeonia lactiflora 芍药属 Paeonia