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Identification of basic fibroblast growth factor-like immunoreactivity in Panax ginseng extract: Investigation of its molecular properties

Authors Takei, Y; Yamamoto, T; Higashira, H; Hayashi, K

Journal BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY , APR 1996,4:60

DOI 10.1271/bbb.60.584 PubMed 8829523

Abstract Basic fibroblast growth factor (bFGF)-like immunoreactivity was detected in extracts of Panax ginseng root by using a sensitive two-site enzyme immunoassay specific for human bFGF (hbFGF). In an investigation of the molecular properties of this bFGF-like molecule (bFGF-LI), the bFGF-LI and hbFGF were found to be equivalent with respect to antigenicity, molecular weight, isoelectric point, affinity for binding to heparin, and mitogenic activity toward BALB/c3T3 fibroblasts. The identification of this bFGF-LI molecule in Panax ginseng root helps to explain various activities of the traditional Chinese medicine ginseng.

Species covered 人参 Panax ginseng