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Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine

Authors Sonoda, M; Nishiyama, T; Matsukawa, Y; Moriyasu, M

Journal JOURNAL OF ETHNOPHARMACOLOGY , MAR 2004,1:91

DOI 10.1016/j.jep.2003.11.014 PubMed 15036470

Abstract The effects of 17 favonoids, isolated from two favonoid-rich Scutellaria species (Scutellaria baicalensis Georgi and Scutellaria rivularis Wall) used in traditional Chinese medicine, on HL-60 cells were assessed by WST-8. Ten of the flavonoids inhibited the proliferation of HL-60, as shown by IC50 values used as indexes of the inhibition. 2'',3'',5,7-tetrahydroxy flavone (IC50 = 9.5 muM), apigenin (15.0 muM), viscidulin III (17.4 muM), wogonin (17.4 muM) and luteolin (18.4 muM) were more effective than baicalein (23.0 muM) which reportedly inhibits the proliferation of some cancer cell lines. Others were less effective, and oroxylin A stimulated the proliferation. Scutellaria rivularis, used for the treatment of tumors in the clinic, contained flavonoids that were more inhibitive than those in Scutellaria baicalensis. These results are demonstrative of some reasons for the use of Scutellaria rivularis as a crude antitumor drug. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Species covered 黄芩 Scutellaria baicalensis 半枝莲 Scutellaria barbata