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[Inhibition of protein kinase C by stilbenoids].

作者 Xu, G; Zhang, L P; Chen, L F; Hu, C Q

期刊 Yao xue xue bao = Acta pharmaceutica Sinica , 1994,11:29

PubMed 7863783

摘要 The effect of 15 stilbenoids on protein kinase C (PKC) was studied in order to search for naturally occurring PKC inhibitors. All these compounds were isolated from Chinese medicines. Three oligomeric stilbenes from Caragana sinica, alpha-viniferin, kobophenol A and miyabenol C, were shown to intensely inhibit the activity of partially purified rat brain PKC with IC50 values of 62.5, 52.0, and 27.5 mumol.L-1, respectively. Kinetic analyses revealed that that inhibition was noncompetitive. The other compounds also showed the effect. Monomer stilbenes exhibited PKC inhibitory activity at higher mumol.L-1 concentrations than oligomeric stilbenes. Whenever they are methylated or acetylated perfectly, the inhibition weakens or disappears.

涉及物种 锦鸡儿 Caragana sinica