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Constituents and pharmacological effects of Eucommia and Siberian ginseng

Authors Deyama, T; Nishibe, S; Nakazawa, Y

Journal ACTA PHARMACOLOGICA SINICA , DEC 2001,12:22

PubMed 11749801

Abstract The bark and leaves of Eucommia ulmoides Oliv Eucommiaceae) and Siberian ginseng (Ezoukogi in Japanese) prepared from the root bark or stem bark of Eleutherococcus senticosus Maxim (Acanthopanax senticosus Ham-is) have been used as tonic and anti-stress drug. The extracts of Eucommia showed anti-hypertensive, anti-complementary, anti-oxidative, and antigastric ulcer effects, and promoting collagen synthesis, accelating granuloma formation, and other pharmacological effects. The Siberian ginseng exhibited anti-fatigue, anti-stress, immuno-enhancing effect, CNS activity, and anti-depressive effect. By now, 40, 28, and 10 compounds have been isolated from Eucommia ulmoides bark, Eucommia ulmoides leaves, and Siberian ginseng, respectively, and their structures were elucidated. Their pharmacological activities were mainly due to lignans and iridoid glycosides.

Species covered 杜仲 Eucommia ulmoides 刺五加 Acanthopanax senticosus