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Two New Limonoids from the Root Bark of Chinese Medicinal Plant Dictamnus dasycarpus

Authors Wang, Li-Li; Jiang, Cheng-Shi; Fu, Yan; Chen, Fei-Fei; Lan, Le-Fu; Zhang, Hai-Yan; Guo, Yue-Wei

Journal HELVETICA CHIMICA ACTA , SEP 2014,9:97

DOI 10.1002/hlca.201400027

Abstract Two new limonoids, kihadanin C (1) and 23-methoxydasylactone A (2), together with seven related known ones, 3-9, were isolated from the root bark of the plant Dictamnus dasycarpus. The structures of the new compounds were elucidated on the basis of extensive analyses of their spectroscopic data (1D- and 2D-NMR, MS) and by comparison of their NMR data with those reported in the literature. To the best of our knowledge, 1 presents the first example of A, D-seco limonoid with an unusual 3,4-dihydroxy-2,5-dimethoxytetrahydrofuran moiety as ring E. In the bioassay in vitro, 7 showed moderate antibacterial activity against Staphylococcus aureus, while 8 and 9 displayed neuroprotective activities against H2O2-induced injury in SH-SY5Y cells.

Species covered 白鲜 Dictamnus dasycarpus