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In vivo pharmacokinetics of bakuchiol after oral administration of bakuchiol extraction in rat plasma

Authors Yan, Dong-Mei; Chang, Yan-Xu; Wang, Yue-Fei; Liu, Er-Wei; Li, Jin; Kang, Li-Yuan; Gao, Xiu-Mei

Journal JOURNAL OF ETHNOPHARMACOLOGY , APR 21 2010,3:128

DOI 10.1016/j.jep.2009.12.039 PubMed 20051255

Abstract Ethnopharmacological relevance: Psoralea corylifolia L (Fabaceae) was a traditional Chinese medicine for the treatment of various skin diseases such as psoriasis, vitiligo and chronic graft-versus-host, and has been proved to show anticancer, cytotoxic, anti-bacterial, cardiac, diaphoretic, diuretic, stimulant, aphrodisiac and tonic effects. Bakuchiol was one of the main active ingredients of this traditional Chinese medicine.Aim of the study: In this paper, pharmacokinetic study was conducted to obtain pharmacokinetic parameters of bakuchiol.Materials and methods: Bakuchiol was enriched using resin inform the ethanol extract of Psoralea corylifolia L, HPLC-UV was used to determine the concentration of bakuchiol in rat plasma at different time points after administration. The main pharmacokinetic parameters of bakuchiol in rat were obtained based on the analysis of the plasma sample.Results: The pharmacokinetics of bakuchiol was fitted with a two-compartment model and it was eliminated relative slowly in rats.Conclusions: The HPLC-UV method was successfully applied to study the pharmacokinetics of bakuchiol in rats. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Species covered 补骨脂 Psoralea corylifolia