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Cytotoxic alkaloids from Houttuynia cordata

Authors Kim, SK; Ryu, SY; No, J; Choi, SU; Kim, YS

Journal ARCHIVES OF PHARMACAL RESEARCH , DEC 2001,6:24

DOI 10.1007/BF02975156 PubMed 11794526

Abstract Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.

Species covered 蕺菜 Houttuynia cordata