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Effect of Rhizoma Polygonati on 12-O-tetradecanoylphorbol-acetate-induced ear edema in mice

作者 Xian, Yan-Fang; Lin, Zhi-Xiu; Xu, Xin-Yi; Su, Zi-Ren; Chen, Jian-Nan; Lai, Xiao-Ping; Ip, Siu-Po

期刊 JOURNAL OF ETHNOPHARMACOLOGY , AUG 1 2012,3:142

DOI 10.1016/j.jep.2012.06.013 PubMed 22710295

摘要 Ethnopharmacological relevance: Rhizoma Polygonati is originated from the dried rhizomes of Polygonatum sibircum Red. It has long been used in traditional Chinese medicine for the treatment of inflammatory disorders.Aim of the study: The present study aims to investigate the anti-inflammatory effect of aqueous extract of Rhizoma Polygonati (ERP) in a mouse model of inflammation induced by 12-O-tetradecanoylphorbol-acetate (TPA).Materials and methods: The anti-inflammatory effect was evaluated by measuring the ear thickness and activity of myeloperoxidase (MPO). The anti-inflammatory mechanism was explored by determining the protein and mRNA levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6.Results: The results showed that ERP significantly decreased the ear thickness and MPO activity in mouse model of inflammation induced by TPA. In addition, ERP also remarkably inhibited the protein and mRNA levels of iNOS, COX-2, TNF-alpha, IL-1 beta, and IL-6.Conclusions: These results indicate that ERP has potential anti-inflammatory effect on TPA-induced inflammatory in mice, and the anti-inflammatory effect may be mediated, at least in part, by inhibiting the mRNA expression of a panel of inflammatory mediators including iNOS, COX-2, TNF-alpha, IL-1 beta, and IL-6. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

涉及物种 黄精属 Polygonatum