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Vulgarisin A, a New Diterpenoid with a Rare 5/6/4/5 Ring Skeleton from the Chinese Medicinal Plant Prunella vulgaris

作者 Lou, Huayong; Zheng, Shan; Li, Tianlei; Zhang, Jianxin; Fei, Yue; Hao, Xiaojiang; Liang, Guangyi; Pan, Weidong

期刊 ORGANIC LETTERS , MAY 16 2014,10:16

DOI 10.1021/ol5009763 PubMed 24796480

摘要 Vulgarisin A (1), a new diterpenoid with an unprecedented 5/6/4/5 fused tetracyclic ring skeleton, has been isolated from the medicinal plant Prunella vulgaris Linn. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was secured by single crystal X-ray diffraction analysis. Compound 1 showed weak cytotoxicity against human lung carcinoma A549 cells with an IC50 value of 57.0 mu M.

涉及物种 夏枯草(变种) Prunella vulgaris