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The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or A beta(1-42)-induced cognitive dysfunction in mice

作者 Park, Se Jin; Jung, Jun Man; Lee, Hyung Eun; Lee, Young Woo; Kim, Dong Hyun; Kim, Jong Min; Hong, Jin Gyu; Lee, Chang Hwan; Jung, In Ho; Cho, Yong-Baik; Jang, Dae Sik; Ryu, Jong Hoon

期刊 JOURNAL OF ETHNOPHARMACOLOGY , MAR 13 2015,:162

DOI 10.1016/j.jep.2014.12.065 PubMed 25562722

摘要 Ethnopharmacological relevance: Alzheimer''s disease is a neurodegenerative disorder associated with cognitive impairment and cholinergic neuronal death. INM-176 is a standardized ethanolic extract of Angelica gigas Nakai that has been traditionally used in herbal medicine in China, Japan, and Korea to treat anemia or as a sedative. We investigated whether INM-176 exhibits anti-amnesic effects.Materials and methods: Memory impairment was induced by scopolamine, a cholinergic muscarinic receptor antagonist, or amyloid beta(1-42) (A beta(1-42)) protein. Anti-amnesic effects of INM-176 were measured by the passive avoidance and the Morris water maze tasks in mice. We also examined the effect of INM-176 on the acetylcholinesterase activity, as well as A beta(1-42) protein-induced astrogliosis or cholinergic neuronal loss in the brain.Results: Scopolamine-induced cognitive dysfunction was significantly attenuated by a single or sub-chronic administration of INM-176 in the passive avoidance and the Morris water maze tasks. A single or sub-chronic administration of INM-176 also ameliorated memory impairments induced by A beta(1-42) protein. INM-176 inhibited acetylcholinesterase activity in the hippocampal tissue in vitro and ex vivo. In addition, INM-176 attenuated the A beta(1-42) protein-induced astrocyte activation in the hippocampus as well as cholinergic neuronal damage in the CA3 region of the hippocampus and the nucleus basalis of Meynert.Conclusion: These results suggest that the memory ameliorating effects of INM-176 on scopolamine- or A beta(1-42) protein-induced memory impairment are mediated, in part, via acetylcholinesterase inhibition and neuroprotective activities. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

涉及物种 朝鲜当归 Angelica gigas