Authors Kang, Moonkyu; Jung, Inho; Hur, Jonghyun; Kim, Soon Han; Lee, Jeong Hun; Kang, Ji-Yun; Jung, Kyoung Chul; Kim, Kyoung Soo; Yoo, Myung Chul; Park, Dong-Suk; Lee, Jae-Dong; Cho, Yong-Baik
Journal JOURNAL OF ETHNOPHARMACOLOGY , SEP 15 2010,2:131
DOI 10.1016/j.jep.2010.07.025 PubMed 20643199
Abstract Ethnopharmacological relevance : Lonicera Japonica Thunb and Anemarrhena asphodeloides BUNGE have been used for the treatment of a variety of inflammatory diseases, cold and infective diseases in many countries. Including Korea and China.Aim of the study: This study aimed to assess the anti-nociceptive and anti-inflammatory activities of n-butanol fraction (WIN-34B) prepared from dried flowers of Lonicera japonica and dried roots of Anemarrhena asphodeloides as potential novel treatment of osteoarthritisMaterials and methods: Anti-nociceptive activities of WIN-34B (100, 200 and 400 mg/kg, p o) were measured using acetic acid-Induced writhing response, formalin-induced paw licking, hot plate, radiant heat tail-flick, carrageenan-induced paw pressure, and Hargreaves tests, respectively Anti-Inflammatory activities of WIN-34B (100, 200 and 400 mg/kg, p.o.) were assessed using acetic acid-induced vascular permeability, carrageenan-induced paw edema, and croton oil-induced car edema Anti-osteoarthritis effect of WIN-34B was analyzed using monosodium lodoacetate (MIA)-induced osteoarthritis animal model.Results: WIN-34B exhibited better anti-Inflammatory activity than that of celecoxib in carrageenan at the dose of 200 mg/kg and croton oil-induced paw edema and ear edema at the doses of 200 and 400 mg/kg WIN-34B exhibited significant anti-inflammatory effects on vascular permeability. WIN-34B also exhibited significant anti-nociceptive activities in the late phase of formalin-induced paw licking and writhing response model in mice. In radiant heat tail-flick and carrageenan-induced paw pressure tests, WIN-34B at the dose of 400 mg/kg and at the doses of 200 and 400 mg/kg presented similar activities to indomethacin and celecoxib. Compared to indomethacin WIN-34B at 400 mg/kg showed similar or better anti-nociceptive activities after 1 and 2 h of theraphy in the hot plate test and better anti-nociceptive activity than that of celecoxib in Hargreves test. In the MIA-induced osteoarthritis animal models. WIN-34B at 400 mg/kg exhibited similar or better anti-nociceptive property than that of celecoxib throughout the pain measurement periodsConclusion. When compared to celecoxib, WIN-34B exhibited similar or better anti-nociceptive and anti-inflammatory activities in osteoarthritic animal models, which may become a potential novel treatment for osteoarthritis. (C) 2010 Elsevier Ireland Ltd All rights reserved.
Species covered 知母 Anemarrhena asphodeloides 忍冬 Lonicera japonica
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