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Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans

Authors Duan, Lin; Tao, Hong-Wen; Hao, Xiao-Jiang; Gu, Qian-Qun; Zhu, Wei-Ming

Journal PLANTA MEDICA , AUG 26 2013,1:149

DOI 10.1016/j.jep.2013.06.052 PubMed 23838475

Abstract Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures were elucidated as (-)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)phenyl]-1-nonanone (1) and (7R,8R)-7,8-dihydro-7-(3,4-dihydroxyphenyl)-3''-methoxy-8- methyl-1''-(E-propenyl)benzofuran (2). In addition, the absolute configuration of (+)-Delta 8''-7-acetoxy-3,4,3'',5''-tetramethoxy-8-O-4''-neolignan (3) was determined for the first time through spectroscopic and chemical methods. Their antioxidative activities against 2,2-diphenyl-1-picrylhydrazyl radical and cytotoxicity against K-562 cells were tested, and (7S,8S,7''R,8''S)-4,5''-diliydroxy-3,3''-dimethoxy-7,7''-epoxylignan (4) showed the corresponding activities with IC50 values of 39.4 and 2.11 mu M, respectively.

Species covered 肉豆蔻 Myristica fragrans