Chemical study on compatibility of medicinal plants in Aconitum L. and their processed products with Fritillariae Thunberglii Bulbus and Fritillariae Cirrhosae Bulbus

Authors Dong Xin; Wang Shumin; Zhu Enzhi; Song Fengrui; Liu Zhiqiang; Liu Shuying

Journal Chinese Traditional and Herbal Drugs , 2012,2:43

Abstract Objective To investigate diester-diterpenoid alkaloids content in the decoctions before and after Aconiti Radix, Aconiti Radix Cocta, Aconiti Kusnezoffii Radix, Aconiti Kusnezoffii Radix Cocta, Aconiti Lateralis Radix Praeparata, Radix Aconiti Lateralis Preparata combined with Fritillariae Thunberglii Bulbus and Fritillariae Cirrhosae Bulbus and study the conversion of alkaloids in decoctions. Methods To quantitatively detect the content of diester-diterpenoid alkaloids in decoctions of plants in Aconitum L. and their processed products combined with Fritillariae Thunberglii Bulbus and Fritillariae Cirrhosae Bulbus by HPLC and ESI-MS. Results Decoctions containing Fritillariae Thunberglii Bulbus could inhibit the hydrolysis and conversion of alkaloids, while those containing Fritillariae Cirrhosae Bulbus could promote the transformation of alkaloids and reduce their content. Conclusion Analyses of content changes of three diester-diterpenoid alkaloids indicate that the statement of aconite counteracts fritillaria is not comprehensive medicinal plants in Aconitum L. and their processed products combined with Fritillariae Thunberglii Bulbus are counteraction, but with Fritillariae Cirrhosae Bulbus are not.

Species covered 贝母属 Fritillaria