---

Two new cholinesterase inhibitors asiatoates A and B from Buddleja asiatica

作者 Ali, Farman; Khan, Hidayat Ullah; Afzal, Masood; Samad, Abdul; Khan, Shafi Ullah; Ali, Irshad

期刊 JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH , JUN 1 2013,6:15

DOI 10.1080/10286020.2013.794417 PubMed 23659547

摘要 Two new benzoates, asiatoate A (1) and asiatoate B (2), have been isolated from the ethyl acetate soluble fraction of Buddleja asiatica whole plant. Their structures were elucidated with the help of spectroscopic data. Both showed significant inhibitory effect on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner. The IC50 values of compounds 1-2 were 5.54 and 8.34M against AChE while 30.94 and 35.94M against BChE, respectively.

涉及物种 七里香 Buddleja asiatica