Synergistic effects of Artemisia iwayomogi and Curcuma longa radix on high-fat diet-induced hyperlipidemia in a mouse model
作者 Han, Jong-Min; Lee, Jin-Seok; Kim, Hyeong-Geug; Seol, In-Chan; Im, Hwi-Jin; Cho, Jung-Hyo; Son, Chang-Gue
期刊 JOURNAL OF ETHNOPHARMACOLOGY , JUL 2012,7:64
摘要
Ethnopharmacological relevance: The medicinal plants Artemisia iwayomogi and Curcuma longa radix are both used to treat hyperlipidemia in traditional Korean and Chinese medicine.Aim of the study: To evaluate the anti-hyperlipidemic effects of the 30% ethanol extracts of A. iwayomogi (Al), C longa (CL), and the mixture of A. iwayomogi and C longa (ACE), using a high-fat diet-induced hyperlipidemia model.Materials and methods: Six of seven groups of C57BL/6N male mice (i.e., not including the naive group) were fed a high-fat diet freely for 10 weeks. Of these six groups, five (i.e., not including the control group) were administered a high-fat diet supplemented with Al (100 mg/kg), CL (100 mg/kg), ACE (50 or 100 mg/kg), or Lipitor (20 mg/kg). Serum lipid profiles, obesity-related markers, hepatic steatosis, hepatic gene expression, and oxidative stress markers were analyzed.Results: Al, CL, and ACE were associated with significant effects on serum lipid profiles (total cholesterol [TC] and triglyceride), body, liver and peritoneal adipose tissue weights, hepatic lipid accumulation, and oxidative stress biomarkers. ACE at 100 mg/kg was associated with significantly greater improvements in serum TC and triglyceride, hepatic triglyceride, epididymal adipocyte size, and oxidative stress biomarkers, compared with Al and CL Al, CL and ACE normalized lipid synthesis-associated gene expression (peroxisome proliferator-activated receptor gamma, fatty acid synthase, sterol regulatory element-binding transcription factor-1c, and peroxisome proliferator-activated receptor alpha).Conclusion: ACE exhibits anti-hyperlipidemia properties and is associated with partially synergistic effects compared with Al or CL alone. (C) 2015 Elsevier Ireland Ltd. All rights reserved.