In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms
作者 Zhang, CZ; Wang, SX; Zhang, Y; Chen, JP; Liang, XM
期刊 JOURNAL OF ETHNOPHARMACOLOGY , APR 26 2005,3:98
摘要
The estrogenic activity of 70% EtOH extracts of 32 traditional Chinese medicinal plants, selected according to their reported efficacy for the treatment of menopausal symptoms, was assessed using a recombinant yeast system with both a human estrogen receptor expression plasmid and a reporter plasmid. Among them, 11 (34%) species proved to be active. Polygonum to cuspidatum had the highest estrogenic relative potency (RP) (3.28 x 10(-3)), followed by Rheum palmatum (3.85 x 10(-4)), Cassia obtusifolio (3.49 x 10(-4)), Polygonum multiflorum (2.87 x 10(-4)), Epimedium brevicormum (2.30 x 10(-4)), Psoralea corylifolia (1.90 x 10(-4)), Cynomorium songaricum (1.78 x 10(-4)), Belamcanda chinensis (1.26 x 10(-4)). Scutellaria baicalensis (8.77 x 10(-5)), Astragalus membranaceus (8.47 x 10(-5)) and Puerario lobata (6.17 x 10(-5)). The EC50 value of 17 beta-estradiol used as the positive control was 0.205 +/- 0.025 ng/ml (RP = 100). This study gave support to the reported efficacy of Chinese medicines used for hormone replacement therapy. (c) 2005 Elsevier Ireland Ltd. All rights reserved.